Amethoflavone

PhytochemicalFlavonoid

What is it

Amethoflavone is a sometimes-misspelled or misused supplement-label name (likely intending amentoflavone), a biflavonoid found in plants such as Ginkgo biloba, St. John's wort, and Selaginella species.

Evidence for 2 uses

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Anxiolytic / GABA-A modulation

Mixed Evidence

Preclinical only; no human evidence.

Aromatase inhibition

Mixed Evidence

In vitro activity; no human evidence for clinically meaningful estrogen change.

How it works

Amentoflavone is a dimeric flavonoid that has shown a wide range of effects in preclinical models: GABA-A receptor modulation (with apparent benzodiazepine-like activity in vitro), aromatase inhibition, anti-inflammatory effects, and modest cytochrome P450 inhibition (notably CYP3A4 and CYP2C9). Bioavailability after oral intake is limited due to low solubility and extensive first-pass metabolism. Human clinical evidence on isolated amentoflavone is minimal.

Dosage

No established dose. Sold in some 'natural anxiolytic' or aromatase-inhibitor blends in variable amounts.

When and how to take it

No established timing.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Amentoflavone (isolated)

Rarely sold pure.

Limited oral bioavailability.

Safety

Limited human safety data. CYP inhibition raises concerns about drug interactions.

Who should be cautious

Avoid in pregnancy, breastfeeding, and in anyone on prescription medications metabolized by CYP3A4 or CYP2C9 without medical guidance.

Interactions

Potential significant interactions with medications metabolized by CYP3A4 (statins, calcium-channel blockers, immunosuppressants) and CYP2C9 (warfarin, NSAIDs).

Food sources

Ginkgo biloba leaf

Amount
as extract
%DV
—

Frequently asked questions

Is amentoflavone safe with my medications?⌄

It may inhibit drug-metabolizing enzymes. Discuss with a pharmacist or physician before combining with other medications.

Does it work as an anxiolytic?⌄

No human evidence supports an anxiolytic effect.

References

Amethoflavone on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Amethoflavone (PubMed search) — PubMed link

Track Amethoflavone with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.