Alpha-cyclodextrin

Alpha-cyclodextrin is fermented in the colon, where it contributes to short-chain fatty acid production typical of soluble fibers. As a delivery vehicle, its ring shape forms inclusion complexes with small molecules (vitamins, flavors, lipids), which can improve solubility, stability, or taste of the encapsulated ingredient. It has also been studied as a fat binder under the trade name FBCx, where it forms complexes with dietary fats in the gut and reduces their absorption. Several small RCTs have looked at its effect on blood lipids in this context.

There is no RDA. As a fiber, 5 to 6 g per day is typical in clinical studies. As a fat binder, doses of 2 to 6 g taken with meals have been used.

When used as a fat binder, take immediately before or with fat-containing meals. When used as a general fiber, distribute through the day with adequate water.

Alpha-cyclodextrin has GRAS status from the FDA. High doses can cause gas, bloating, and loose stools, common to soluble fibers. No serious adverse effects have been reported in clinical use.

Because it forms complexes with lipophilic molecules, theoretically it could reduce absorption of fat-soluble vitamins or lipophilic drugs taken at the same time. Clinical relevance at typical doses appears modest.