Salt Substitute Interactions

Most salt substitutes are made primarily of potassium chloride and can deliver 500 mg or more of potassium per quarter teaspoon. Spironolactone is a potassium-sparing diuretic that markedly reduces renal potassium excretion. Combining the two can cause severe, sometimes fatal hyperkalemia.

Salt substitutes are typically potassium chloride and can deliver hundreds of milligrams of potassium per small serving. Lisinopril and other ACE inhibitors reduce aldosterone and decrease potassium excretion. Combining them can cause clinically significant hyperkalemia, particularly with chronic kidney disease, diabetes, or other potassium-raising drugs.