Saffron Interactions
3 documented interactions — 2 warnings, 1 beneficial pair.
View the full Saffron supplement guide →Interaction warnings
Saffron + fluoxetine
moderateSaffron (Crocus sativus) has independent antidepressant activity, including serotonergic effects demonstrated in randomized controlled trials, and combining it with fluoxetine can theoretically add to serotonergic tone. Fluoxetine's long half-life extends the window of potential interaction for weeks after the last dose.
Saffron + antidepressants
moderateSaffron and its constituents crocin and safranal show antidepressant activity by inhibiting serotonin, norepinephrine, and dopamine reuptake and modulating monoamine oxidase, which is additive to SSRIs, SNRIs, and MAOIs and raises the theoretical risk of serotonin syndrome.
Beneficial pairs
Related ingredients
Ingredients commonly checked alongside Saffron.
