Resveratrol Interactions

Spermidine and resveratrol both induce autophagy but through different upstream mechanisms: spermidine inhibits histone acetyltransferases (lowering histone acetylation), while resveratrol activates the sirtuin SIRT1 (a deacetylase). The two converge on the acetylproteome and have been shown to synergize at low doses for autophagy induction and lifespan extension in model organisms.

Quercetin inhibits the sulfotransferase and UDP-glucuronosyltransferase enzymes that rapidly clear resveratrol, prolonging its plasma half-life and free fraction. The two polyphenols also act synergistically on antioxidant and SIRT1-related longevity pathways in cell and animal studies.