Licorice Tea Interactions

Licorice (Glycyrrhiza glabra) contains glycyrrhizin, which inhibits renal 11-beta-hydroxysteroid dehydrogenase type 2 and causes potassium loss through mineralocorticoid-like activity. The resulting hypokalemia sharply increases digoxin's binding to cardiac Na/K-ATPase, raising the risk of life-threatening digoxin toxicity and arrhythmia.