Diazepam Interactions

Diazepam (Valium) and alcohol are both GABA-A receptor positive allosteric modulators, producing additive and supra-additive CNS depression with profound risk of respiratory depression, coma, and death. Diazepam's long half-life and active metabolites extend the window of dangerous interaction far beyond the dosing interval.

Kava's kavalactones bind GABA-A receptors and produce additive central nervous system depression when combined with diazepam, a long-acting benzodiazepine. Concurrent use is not recommended due to risk of excessive sedation, impaired coordination, and potential additive hepatotoxicity.