Chromium Interactions

Chromium increases insulin sensitivity at the muscle cell, which means each unit of injected insulin produces a larger glucose-lowering effect than your dose was calibrated for. The result can be unpredictable hypoglycemia, particularly between meals and overnight when basal insulin is acting.

Chromium can increase insulin sensitivity and lower fasting blood glucose, producing an additive effect when stacked on top of metformin. The combination can drive blood sugar below the range that the metformin dose was calibrated for, raising the risk of hypoglycemia symptoms (shakiness, sweating, confusion) even though metformin alone rarely causes lows.