Cayenne Interactions

Capsaicin, the active constituent in cayenne (Capsicum), has been reported to potentiate the anticoagulant effect of warfarin, theoretically through additive effects on platelet aggregation and possible enhancement of warfarin absorption or activity, increasing bleeding risk.

Capsaicin, the active component of cayenne, can trigger or worsen the dry cough characteristic of ACE inhibitor therapy by sensitizing airway cough receptors. A published case report describes topical capsaicin inducing cough in a patient already on an ACE inhibitor.