Cayenne Interactions

Capsaicin, the active constituent in cayenne (Capsicum), is theorized to add modestly to warfarin's blood-thinning effect through additive antiplatelet activity and possible effects on drug metabolism. The interaction is mechanistic; we found no documented human bleeding cases specific to cayenne plus warfarin.

Capsaicin, the active compound in cayenne, acts on the same airway cough receptors that ACE inhibitors sensitize, so it may trigger or worsen the dry cough some people get on ACE inhibitor therapy. The evidence is a single older case report plus consistent mechanism; the effect is a nuisance, not a danger, and cayenne does not reduce how well the medication works.