Bergamot Interactions

Bergamot orange (Citrus bergamia) is the source of bergamottin, the prototype furanocoumarin that irreversibly inhibits CYP3A4. Bergamot juice and high-dose bergamot polyphenol supplements (BPF), often marketed for cholesterol, can theoretically raise levels of CYP3A4-metabolized statins (simvastatin, atorvastatin, lovastatin), though human pharmacokinetic data with statins are limited.