serotonin-syndrome
2 interactions related to serotonin-syndrome
nutmeg + maois
Nutmeg contains myristicin, which has weak monoamine oxidase inhibitor (MAOI) activity. Combining nutmeg supplements or large culinary doses with prescription MAOIs can theoretically precipitate hypertensive crisis or serotonin syndrome through additive MAO inhibition.
nutmegmyristicinmaoiphenelzinetranylcyprominehypertensive-crisisserotonin-syndromedrug-interaction
saffron + antidepressants
Saffron and its constituents crocin and safranal show antidepressant activity by inhibiting serotonin, norepinephrine, and dopamine reuptake and modulating monoamine oxidase, which is additive to SSRIs, SNRIs, and MAOIs and raises the theoretical risk of serotonin syndrome.
saffroncrocinsafranalssrisnriantidepressantserotonin-syndromedepression