serotonin-syndrome
2 interactions related to serotonin-syndrome
nutmeg + maois
Nutmeg contains myristicin, which a 1963 laboratory study reported to weakly inhibit monoamine oxidase (MAO) in vitro. Because MAOI antidepressants block the same enzyme, the theoretical concern is an additive effect, though no human cases are documented.
saffron + antidepressants
Saffron's active constituents (crocin and safranal) show antidepressant-like activity in laboratory and animal studies, partly through monoamine reuptake and monoamine-oxidase inhibition. This overlaps with how SSRIs, SNRIs, and MAOIs work, raising a theoretical concern about additive serotonergic effects. In practice, human trials combining standardized saffron with fluoxetine or sertraline reported no serotonin syndrome and no serious adverse events, and there are no documented human cases from this combination.