drug-interaction
3 interactions related to drug-interaction
nutmeg + maois
Nutmeg contains myristicin, which a 1963 laboratory study reported to weakly inhibit monoamine oxidase (MAO) in vitro. Because MAOI antidepressants block the same enzyme, the theoretical concern is an additive effect, though no human cases are documented.
cayenne + ace inhibitors
Capsaicin, the active compound in cayenne, acts on the same airway cough receptors that ACE inhibitors sensitize, so it may trigger or worsen the dry cough some people get on ACE inhibitor therapy. The evidence is a single older case report plus consistent mechanism; the effect is a nuisance, not a danger, and cayenne does not reduce how well the medication works.
black pepper + propranolol
Piperine, the active alkaloid in black pepper, can inhibit intestinal P-glycoprotein and several liver enzymes that normally limit how much propranolol reaches the bloodstream. A small human study found that concentrated piperine raised propranolol's blood levels, so a stable dose may behave like a somewhat higher one, slightly amplifying its blood-pressure and heart-rate effects. Culinary pepper is not the concern; concentrated piperine supplements are.