drug-interaction
3 interactions related to drug-interaction
nutmeg + maois
Nutmeg contains myristicin, which has weak monoamine oxidase inhibitor (MAOI) activity. Combining nutmeg supplements or large culinary doses with prescription MAOIs can theoretically precipitate hypertensive crisis or serotonin syndrome through additive MAO inhibition.
cayenne + ace inhibitors
Capsaicin, the active component of cayenne, can trigger or worsen the dry cough characteristic of ACE inhibitor therapy by sensitizing airway cough receptors. A published case report describes topical capsaicin inducing cough in a patient already on an ACE inhibitor.
black pepper + propranolol
Piperine, the active alkaloid in black pepper, inhibits CYP3A4, CYP2C9, and intestinal P-glycoprotein, increasing the oral bioavailability and serum concentration of propranolol and other beta-blockers, which can amplify blood pressure and heart rate reduction.