zoloft
3 interactions related to zoloft
caffeine + sertraline
Caffeine and sertraline do not share a receptor, but their side-effect profiles overlap. Both can cause anxiety, jitteriness, insomnia, stomach upset and headache, so these symptoms can stack — most noticeably during the first few weeks of sertraline treatment. Unlike fluvoxamine, sertraline does not meaningfully slow caffeine clearance.
cbd + sertraline
CBD inhibits CYP2C19, one of several enzymes that help break down sertraline, so adding CBD can raise sertraline exposure. A single published case report describes low sodium (hyponatremia) and cognitive decline in an older intermediate-metabolizer patient who added over-the-counter CBD to long-standing sertraline. The evidence is limited to this one report, so treat it as a reason for caution and prescriber discussion rather than a strong contraindication.
alcohol + sertraline
Sertraline (Zoloft) and alcohol both act on the central nervous system. Controlled studies in healthy volunteers did not show sertraline worsening alcohol's effects on thinking or coordination, but the FDA label still advises against drinking on sertraline because alcohol can deepen depression and anxiety, worsen drowsiness and sleep, and blunt the medication's benefit in people being treated for a mood disorder.