zoloft
3 interactions related to zoloft
caffeine + sertraline
Sertraline and caffeine can each contribute to anxiety, insomnia, tremor and GI upset, and sertraline may modestly slow caffeine clearance via CYP1A2 inhibition. The pharmacokinetic effect is small but the additive symptomatic effect can be uncomfortable.
cbd + sertraline
CBD inhibits CYP2C19, an enzyme that contributes to sertraline metabolism. A published case report describes severe hyponatremia and cognitive dysfunction in a CYP2C19 intermediate metabolizer who added over-the-counter CBD to chronic sertraline, consistent with phenoconversion to a poor-metabolizer phenotype.
alcohol + sertraline
Sertraline (Zoloft) and alcohol are both central nervous system depressants. Although controlled studies in healthy subjects showed sertraline did not potentiate alcohol's psychomotor impairment, the FDA label still advises against concurrent use because alcohol can worsen depression, anxiety, drowsiness, and judgment in patients being treated for mood disorders.