z-drug
2 interactions related to z-drug
zolpidem + melatonin
Combining the Z-drug hypnotic zolpidem with melatonin can produce additive next-day drowsiness, impaired thinking, and reduced motor coordination, with the risk most pronounced in older adults. The interaction is primarily pharmacodynamic.
zolpidemambienmelatoninz-drugsedationsleep aidnext-day impairmentdrowsiness
zolpidem + valerian
Zolpidem is a Z-drug hypnotic that selectively binds the GABA-A receptor's alpha-1 subunit. Valerian's valerenic acid also modulates GABA-A receptors, producing additive sedation and a documented delay in next-morning psychomotor recovery when the two are combined.
zolpidemambienvalerianz-drugcns depressiongabasleep aidnext-day impairment