1 interaction related to yohimbe
Caffeine and yohimbine are both stimulants that activate the sympathetic ('fight or flight') nervous system through different routes. Caffeine blocks adenosine receptors and raises catecholamine output; yohimbine blocks alpha-2 adrenergic receptors, increasing norepinephrine release. Taken together they add to each other's effects on heart rate, blood pressure, and anxiety. Yohimbine-containing products have been linked to emergency-department visits and hospitalizations for fast heart rate, high blood pressure, and severe anxiety.
