xanax
4 interactions related to xanax
alprazolam + melatonin
Melatonin and alprazolam both promote sleep and can produce additive sedation, impaired alertness, and reduced motor coordination when used together. The combination may increase next-day drowsiness and risk during activities like driving.
alcohol + alprazolam
Alcohol and alprazolam (Xanax) both depress the central nervous system through GABA-A receptor potentiation, producing additive sedation, profound respiratory depression, and impaired psychomotor function. The combination significantly increases risk of overdose death, even at moderate doses of each substance.
thc + benzodiazepines
THC and benzodiazepines are both central-nervous-system depressants and produce additive sedation, ataxia, cognitive impairment, and respiratory slowing. THC and CBD components of cannabis also inhibit CYP3A4, which metabolizes alprazolam, midazolam, and triazolam, potentially raising benzodiazepine plasma levels.
alprazolam + grapefruit
Grapefruit juice contains furanocoumarins that inhibit intestinal CYP3A4, the enzyme that partially metabolizes alprazolam. The interaction can raise alprazolam blood levels and prolong sedation, although the magnitude is modest compared to other benzodiazepines because alprazolam has high oral bioavailability.