warning
4 interactions related to warning
sertraline + 5-htp
Sertraline blocks serotonin reuptake and 5-HTP (5-hydroxytryptophan) is the immediate biochemical precursor of serotonin, so it directly increases serotonin synthesis. Combining the two stacks production and reuptake blockade, which can precipitate serotonin syndrome.
sertraline + sam-e
SAM-e (S-adenosyl-L-methionine) has its own antidepressant and serotonergic effects, and combining it with the SSRI sertraline can additively raise serotonergic activity and increase the risk of serotonin syndrome. Case reports describe mania and serotonin-toxicity-like presentations in patients combining SAM-e with SSRIs.
fluoxetine + 5-htp
Fluoxetine is an SSRI that blocks serotonin reuptake, and 5-HTP is the direct precursor that the body converts into serotonin. Combining them can raise synaptic serotonin to levels associated with serotonin syndrome, and fluoxetine's long-lived active metabolite norfluoxetine extends this risk for weeks after the last dose.
sertraline + tryptophan
Sertraline is a selective serotonin reuptake inhibitor (SSRI) that increases synaptic serotonin, and L-tryptophan is the dietary precursor to serotonin. Combining them can excessively elevate serotonergic activity, raising the risk of serotonin syndrome (agitation, tremor, hyperthermia, autonomic instability).