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4 interactions related to warning
sertraline + 5-htp
Sertraline blocks serotonin reuptake and 5-HTP (5-hydroxytryptophan) is the immediate precursor of serotonin, so it directly increases serotonin synthesis. Combining the two stacks production and reuptake blockade, which can precipitate serotonin syndrome.
sertraline + sam-e
SAM-e (S-adenosyl-L-methionine) has its own antidepressant and serotonergic activity, so combining it with the SSRI sertraline can add serotonergic effects on top of each other. Case reports describe serotonin-toxicity-like presentations and treatment-emergent mania in patients combining SAM-e with serotonergic antidepressants.
fluoxetine + 5-htp
Fluoxetine is an SSRI that blocks serotonin reuptake, and 5-HTP is a direct precursor the body converts into serotonin. Combining them can push serotonin to levels associated with serotonin syndrome, and fluoxetine's long-lived active metabolite norfluoxetine extends this risk for weeks after the last dose.
sertraline + tryptophan
Sertraline is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin signaling, and L-tryptophan is the dietary precursor your body converts into serotonin. Taking them together can push serotonergic activity too high, raising the risk of serotonin syndrome (agitation, tremor, sweating, fast heart rate, and in severe cases fever, rigidity, and seizures).