vitamin b7
4 interactions related to vitamin b7
carbamazepine + biotin
Carbamazepine reduces biotin status by inhibiting sodium-dependent biotin uptake in the intestine, decreasing renal reabsorption, and accelerating biotin catabolism through enzyme induction; long-term users often have measurably lower plasma biotin and elevated organic-acid markers of biotin insufficiency.
biotin + troponin test
High-dose biotin (vitamin B7) interferes with biotin-streptavidin-based immunoassays used to measure cardiac troponin, producing falsely low results that can mask an evolving heart attack. The FDA has received reports of patient harm, including one death linked to a missed myocardial infarction diagnosis caused by biotin-altered troponin readings.
valproate + biotin
Valproate appears to reduce biotinidase activity and impair mitochondrial biotin handling, leading to subnormal biotin status that has been linked to the drug's signature alopecia (hair loss) and brittle nails; biotin supplementation has reversed hair loss in case reports.
biotin + thyroid stimulating hormone test
High-dose biotin interferes with biotin-streptavidin-based immunoassays used to measure TSH, free T3, free T4, and thyroglobulin, producing a falsely low TSH and falsely elevated free thyroid hormones, a pattern that mimics Graves' disease. Patients have been incorrectly diagnosed with hyperthyroidism and started on antithyroid drugs because of biotin interference.