vitamin b3
3 interactions related to vitamin b3
atorvastatin + niacin
Adding cholesterol-dose niacin to atorvastatin raises the risk of muscle injury (myopathy, rarely rhabdomyolysis) without improving cardiovascular outcomes in patients already well treated with a statin.
nad+ + niacin
Niacin (nicotinic acid) is a vitamin B3 form the body converts to NAD+ through the Preiss-Handler pathway, so pairing low, vitamin-level niacin with a direct NAD+ precursor gives cells more than one biosynthetic route to build their NAD+ pool. Niacin has been shown to raise muscle and blood NAD+ in mitochondrial myopathy, though no human trial has tested combining it with direct NAD+, NR, or NMN — the synergy is plausible additive biology rather than a proven stack.
niacin + tryptophan
Niacin (vitamin B3) and the amino acid tryptophan are nutritionally linked: the body can make niacin from tryptophan through the kynurenine pathway, so the two together support the NAD/NADP coenzyme pools that power energy metabolism. Adequate niacin also frees up tryptophan for serotonin and melatonin production. This is a beneficial nutritional partnership, not a hazardous interaction.