vdr
2 interactions related to vdr
probiotics + vitamin d
Vitamin D and probiotics act on overlapping pathways in the gut. Vitamin D supports vitamin D receptor (VDR) activity in the intestinal lining, which probiotics rely on for their anti-inflammatory and barrier-strengthening effects, while some probiotic strains appear to modestly raise circulating vitamin D. Randomized trials suggest combined supplementation can outperform either alone for some inflammatory and gut-barrier endpoints, though the evidence base is still limited.
vitamin d3 + vitamin a
Vitamin D and vitamin A act through partnered nuclear receptors. Vitamin D's active form binds the vitamin D receptor (VDR), which pairs with the retinoid X receptor (RXR) — whose ligand comes from vitamin A — to switch on genes for immunity, epithelial health, and bone. Adequate levels of both support this signaling, but at extreme doses they can work against each other for calcium and bone endpoints, where a controlled human study showed high preformed vitamin A blunting vitamin D's calcium response.