valium
3 interactions related to valium
diazepam + kava
Kava's kavalactones bind GABA-A receptors and produce additive central nervous system depression when combined with diazepam, a long-acting benzodiazepine. Concurrent use is not recommended due to risk of excessive sedation, impaired coordination, and potential additive hepatotoxicity.
alcohol + diazepam
Diazepam (Valium) and alcohol are both GABA-A receptor positive allosteric modulators, producing additive and supra-additive CNS depression with profound risk of respiratory depression, coma, and death. Diazepam's long half-life and active metabolites extend the window of dangerous interaction far beyond the dosing interval.
thc + benzodiazepines
THC and benzodiazepines are both central-nervous-system depressants and produce additive sedation, ataxia, cognitive impairment, and respiratory slowing. THC and CBD components of cannabis also inhibit CYP3A4, which metabolizes alprazolam, midazolam, and triazolam, potentially raising benzodiazepine plasma levels.