valium
3 interactions related to valium
diazepam + kava
Kava's kavalactones act on the GABA-A receptor, the same system diazepam enhances, so combining them produces additive central nervous system depression and excessive sedation. A published case report describes a man who became semicomatose within days of adding kava to a benzodiazepine. Kava also carries a separate, documented liver-safety signal.
alcohol + diazepam
Diazepam (Valium) and alcohol are both central nervous system depressants that act on the GABA-A receptor, producing additive and sometimes greater-than-additive sedation with a real risk of dangerously slowed breathing, loss of consciousness, and death. Diazepam and its active breakdown products linger in the body for days, so the dangerous window extends well beyond a single dose.
thc + benzodiazepines
THC (the main psychoactive compound in cannabis) and benzodiazepines both depress the central nervous system, so combining them adds up to stronger sedation, impaired coordination, memory problems, and slowed breathing. Cannabinoids, especially CBD, can also inhibit the liver enzyme CYP3A4 that clears several benzodiazepines, raising and prolonging their levels.