ulcer
3 interactions related to ulcer
alcohol + naproxen
Naproxen and alcohol combine to substantially increase the risk of stomach bleeding, ulcers, and kidney injury through additive effects on gastric mucosal damage, platelet inhibition, and reduced renal perfusion. Naproxen's longer half-life means the interaction window is more prolonged than with shorter-acting NSAIDs.
alcohol + aspirin
Alcohol and aspirin together significantly increase the risk of gastrointestinal bleeding because aspirin irreversibly inhibits platelets for their entire 7-10 day lifespan while alcohol damages the gastric lining and impairs clot formation. The risk is particularly elevated for daily low-dose aspirin users who drink regularly.
alcohol + ibuprofen
Alcohol and ibuprofen each independently irritate the gastric lining and impair platelet function, and together they significantly increase the risk of gastrointestinal bleeding, ulcers, and acute kidney injury. Chronic combined use also accelerates kidney damage through dehydration and reduced renal perfusion.