ubiquinone
3 interactions related to ubiquinone
simvastatin + coq10
Simvastatin blocks HMG-CoA reductase, the enzyme upstream of both cholesterol and coenzyme Q10 (CoQ10) synthesis, so it lowers circulating CoQ10 alongside cholesterol. This depletion is a plausible contributor to statin-associated muscle symptoms, and some randomized trials suggest CoQ10 supplements modestly ease those symptoms — though the evidence is mixed.
rosuvastatin + coq10
Rosuvastatin blocks HMG-CoA reductase, the enzyme that makes both cholesterol and coenzyme Q10, so it modestly lowers circulating CoQ10. The depletion is generally smaller than with fat-soluble statins, and mitochondrial impairment is only one proposed mechanism for statin-associated muscle symptoms. This is a possible-benefit pairing, not a dangerous one.
atorvastatin + coq10
Atorvastatin inhibits HMG-CoA reductase, the upstream enzyme also needed to make coenzyme Q10 (ubiquinone), so statin therapy lowers blood CoQ10 levels. Mitochondrial CoQ10 depletion is one proposed mechanism for statin-associated muscle symptoms, but evidence that taking CoQ10 reverses those symptoms is modest and mixed. This is a supplement-may-help question, not a harmful interaction.