turmeric
6 interactions related to turmeric
curcumin + ginger
Curcumin and ginger both inhibit NF-kB and COX-2 signaling, but ginger also independently blocks 5-lipoxygenase and contains gingerols and shogaols that suppress prostaglandin and leukotriene synthesis. A randomized trial of a turmeric-black pepper-ginger combination showed efficacy comparable to naproxen for chronic knee osteoarthritis pain.
warfarin + turmeric
Curcumin, the main active in turmeric, has antiplatelet activity and may also inhibit CYP2C9 metabolism of warfarin, raising warfarin levels. New Zealand Medsafe issued an alert in 2018 after a patient's INR rose above 10 within weeks of starting a turmeric/curcumin product on previously stable warfarin therapy.
curcumin + boswellia
Curcumin inhibits NF-kB and dampens COX-2 transcription while boswellic acids (particularly AKBA) selectively block 5-lipoxygenase and leukotriene synthesis. Together they suppress two non-overlapping arms of the inflammatory cascade, giving better symptom relief in osteoarthritis than either alone.
curcumin + fat
Curcumin is a lipophilic molecule with very low water solubility, and dietary fat dramatically improves its dissolution and incorporation into bile acid micelles for intestinal absorption. Lipidic formulations and meals containing fat increase curcumin's plasma exposure compared with intake on an empty stomach.
turmeric + black pepper
Piperine, the active alkaloid in black pepper, inhibits hepatic and intestinal glucuronidation of curcumin and other compounds, and a landmark human study reported a 2000% increase in curcumin bioavailability when 20 mg piperine was co-administered with 2 g curcumin. This is one of the most cited absorption-enhancement combinations in the supplement literature.
turmeric tea + warfarin
Curcumin, the principal active compound in turmeric, has antiplatelet and anticoagulant activity in vitro (inhibiting thrombin and factor Xa) and inhibits CYP enzymes involved in warfarin metabolism. Case reports describe INR rising above 10 within weeks of starting turmeric in patients on stable warfarin.