1 interaction related to transaminases
Taking CBD (including prescription Epidiolex and over-the-counter products) together with valproate raises the chance of liver enzyme elevations well above either drug alone, and the combination has been linked to high blood ammonia that can cause confusion or worsening seizures even when liver tests look only mildly abnormal. This pairing should be managed by the prescribing neurologist with baseline and follow-up liver testing.
