thiazide
3 interactions related to thiazide
hydrochlorothiazide + calcium
Thiazide diuretics such as hydrochlorothiazide increase the kidney's reabsorption of calcium and reduce how much calcium leaves the body in urine. This calcium-sparing effect is often beneficial, but combined with generous calcium supplements, high-dose vitamin D, or underlying parathyroid disease it can push blood calcium too high (hypercalcemia).
hydrochlorothiazide + magnesium
Thiazide diuretics such as hydrochlorothiazide increase urinary magnesium excretion, and a meaningful minority of long-term users become magnesium-depleted. Low magnesium also makes potassium hard to replace and can worsen muscle cramps and heart-rhythm risk.
hydrochlorothiazide + potassium
Hydrochlorothiazide promotes urinary potassium excretion at the distal convoluted tubule and is a common cause of drug-induced low potassium (hypokalemia). Many patients stay low even with food or supplements, while others on combination blood-pressure regimens face the opposite risk of high potassium if a potassium-sparing drug is added. Either direction can affect heart rhythm, so potassium should be supplemented only under medical guidance with blood monitoring.