thiazide
3 interactions related to thiazide
hydrochlorothiazide + calcium
Thiazide diuretics increase renal tubular reabsorption of calcium and reduce urinary calcium excretion, which is therapeutically useful for preventing kidney stones and reducing bone loss. However, this calcium-sparing effect can produce hypercalcemia when combined with high-dose calcium supplements, vitamin D, or in patients with underlying primary hyperparathyroidism.
hydrochlorothiazide + magnesium
Thiazide diuretics increase urinary magnesium excretion and roughly 1 in 5 long-term users develop hypomagnesemia. Low magnesium worsens the hypokalemia that thiazides also cause and can perpetuate refractory potassium depletion.
hydrochlorothiazide + potassium
Hydrochlorothiazide promotes urinary potassium excretion at the distal convoluted tubule and is a leading cause of drug-induced hypokalemia. Many patients still develop low potassium despite supplementation, while some on combination antihypertensives risk the opposite problem if a potassium-sparing agent is added.