1 interaction related to surgery
Higher-dose vitamin E (alpha-tocopherol) can inhibit platelet aggregation through a protein kinase C-dependent mechanism, prolonging bleeding times and producing abnormal results on platelet function tests such as the PFA-100, VerifyNow, and light transmission aggregometry. The effect is most pronounced alongside aspirin or other antiplatelet drugs and can complicate a workup for a suspected bleeding disorder.
