supplement
7 interactions related to supplement
metoprolol + coq10
Beta-blockers like metoprolol inhibit CoQ10-dependent mitochondrial enzymes, gradually depleting CoQ10 levels in heart tissue and potentially contributing to fatigue, exercise intolerance, and reduced cardiac energy production. CoQ10 supplementation does not reduce metoprolol's blood pressure or heart rate effects but may offset these mitochondrial side effects.
maoi + 5-htp
5-HTP is the direct precursor to serotonin and bypasses the rate-limiting step of serotonin synthesis. Combined with an MAOI, which blocks serotonin breakdown, intracellular and synaptic serotonin can rise to toxic levels, producing serotonin syndrome.
sertraline + 5-htp
Sertraline blocks serotonin reuptake and 5-HTP (5-hydroxytryptophan) is the immediate biochemical precursor of serotonin, so it directly increases serotonin synthesis. Combining the two stacks production and reuptake blockade, which can precipitate serotonin syndrome.
liothyronine + calcium
Calcium salts (carbonate, citrate, acetate) can bind thyroid hormone in the gastrointestinal tract and reduce absorption of liothyronine (T3) much as they do with levothyroxine. This can blunt the effect of the dose and lead to suboptimal thyroid replacement.
liothyronine + iron
Iron salts (ferrous sulfate, fumarate, gluconate, bisglycinate) can chelate thyroid hormone in the gut and reduce absorption of liothyronine, similar to the established interaction with levothyroxine. Concurrent dosing can cause inadequate T3 effect and elevated TSH.
fluoxetine + 5-htp
Fluoxetine is an SSRI that blocks serotonin reuptake, and 5-HTP is the direct precursor that the body converts into serotonin. Combining them can raise synaptic serotonin to levels associated with serotonin syndrome, and fluoxetine's long-lived active metabolite norfluoxetine extends this risk for weeks after the last dose.
whey protein + iron
Whey protein contains calcium and bioactive peptides that can chelate iron in the gut and reduce its absorption. Studies in iron-fortified casein-whey drinks show calcium added with whey reduces iron absorption by approximately 18 to 27 percent.