supplement
7 interactions related to supplement
metoprolol + coq10
Metoprolol and other beta-blockers have been shown in laboratory studies to inhibit some CoQ10-dependent enzymes, and long-term beta-blocker therapy is associated with modestly lower CoQ10 levels. There is no absorption clash: CoQ10 does not change metoprolol's blood-pressure or heart-rate effects, and metoprolol does not change how the body uses CoQ10. Whether this depletion meaningfully causes fatigue, or whether CoQ10 supplementation relieves it, rests largely on mechanism rather than interaction-specific trials.
sertraline + 5-htp
Sertraline blocks serotonin reuptake and 5-HTP (5-hydroxytryptophan) is the immediate precursor of serotonin, so it directly increases serotonin synthesis. Combining the two stacks production and reuptake blockade, which can precipitate serotonin syndrome.
maoi + 5-htp
5-HTP is the direct precursor to serotonin and bypasses the rate-limiting step of serotonin synthesis. Combined with an MAOI, which blocks serotonin breakdown, serotonin can rise to dangerous levels and trigger serotonin syndrome, a potentially life-threatening reaction.
liothyronine + calcium
Calcium salts (carbonate, citrate, acetate) can bind thyroid hormone in the gut and reduce absorption of liothyronine (T3), much as they do with levothyroxine. Taking them together can blunt the effect of the dose and lead to less reliable thyroid replacement.
liothyronine + iron
Iron salts (ferrous sulfate, fumarate, gluconate, bisglycinate) can bind thyroid hormone in the gut and reduce absorption of liothyronine, similar to the well-documented interaction with levothyroxine. Taking them at the same time can blunt the T3 effect and let TSH drift upward.
fluoxetine + 5-htp
Fluoxetine is an SSRI that blocks serotonin reuptake, and 5-HTP is a direct precursor the body converts into serotonin. Combining them can push serotonin to levels associated with serotonin syndrome, and fluoxetine's long-lived active metabolite norfluoxetine extends this risk for weeks after the last dose.
whey protein + iron
Whey protein is usually consumed alongside calcium-rich milk minerals, and calcium competes with iron for absorption in the gut. When taken at the same time, a whey-plus-iron serving can modestly lower how much iron you absorb. The effect is largely driven by calcium, is generally modest, and is easily offset by taking a vitamin C source with your iron.