stroke prevention
2 interactions related to stroke prevention
apixaban + st. john's wort
St. John's wort strongly induces both CYP3A4 (apixaban's primary metabolizing enzyme) and P-glycoprotein (its efflux transporter). Co-use accelerates apixaban metabolism and clearance, lowering plasma concentrations and increasing the risk of stroke or thromboembolism.
apixabanst johns wortcyp3a4p-glycoproteindoacstroke preventioneliquisherb-drug interaction
dabigatran + st. john's wort
St. John's wort is a potent inducer of P-glycoprotein (P-gp), the efflux transporter responsible for dabigatran disposition. Co-administration increases dabigatran efflux and reduces plasma concentrations, potentially leading to subtherapeutic anticoagulation and increased risk of stroke or thrombosis.
dabigatranst johns wortp-glycoproteindoacstroke preventionanticoagulantpradaxaherb-drug interaction