stimulant
6 interactions related to stimulant
adderall + st. john's wort
Adderall (amphetamine/dextroamphetamine) raises synaptic norepinephrine, dopamine, and serotonin. St. John's Wort inhibits serotonin, dopamine, and norepinephrine reuptake. Combined, the serotonergic load can produce serotonin syndrome and a hypertensive response, while St. John's Wort's CYP3A4 induction may also alter amphetamine metabolism.
methylphenidate + st. john's wort
Methylphenidate inhibits dopamine and norepinephrine reuptake and modestly affects serotonin signaling. St. John's Wort adds reuptake inhibition of serotonin, dopamine, and norepinephrine, plus weak MAO inhibition. Combination risks serotonin syndrome and a published case series suggests reduced methylphenidate efficacy for ADHD.
ginseng + caffeine
Panax ginseng has its own mild stimulant and sympathomimetic activity that adds to caffeine's effects on heart rate, blood pressure, and CNS arousal. The combination can produce jitteriness, insomnia, palpitations, anxiety, and elevated blood pressure, with greater risk in people with hypertension, arrhythmia, or anxiety disorders.
caffeine + adderall
Caffeine and amphetamine salts are both sympathomimetic stimulants. Combining them raises heart rate and blood pressure, worsens anxiety and insomnia, and increases the risk of palpitations, arrhythmias and panic attacks.
caffeine + yohimbine
Caffeine and yohimbine are both potent stimulants. Yohimbine blocks alpha-2 adrenergic receptors, raising norepinephrine, while caffeine blocks adenosine receptors and amplifies sympathetic output. Combined, they can cause large rises in heart rate and blood pressure, severe anxiety, tremor, panic attacks, arrhythmias, and have been linked to hospital visits and rare cardiovascular events.
guarana + caffeine medications
Guarana seeds contain roughly 2-4 times the caffeine concentration of coffee beans, and the caffeine in guarana adds directly to any caffeine-containing medication (e.g., Excedrin, Fioricet, Cafergot, Anacin, Esgic, NoDoz, Vivarin). The combined caffeine load can exceed safe single-dose thresholds, producing tachycardia, hypertension, jitteriness, GI upset, and insomnia.