st. john's wort
2 interactions related to st. john's wort
st. john's wort + red yeast rice
St. John's wort is a strong inducer of the CYP3A4 enzyme system that clears the statin-like compound (monacolin K, chemically identical to lovastatin) in red yeast rice. Taking them together speeds up how the body breaks down that compound, lowering its levels and weakening red yeast rice's cholesterol-lowering effect. The concern here is loss of benefit rather than toxicity, and the direction is the opposite of CYP3A4-inhibitor interactions, so it does not raise muscle-injury risk.
red yeast ricemonacolin klovastatinstatinst. john's wortcyp3a4inductionefficacy
St. John's Wort + SSRI
St. John's Wort is pharmacologically active, not a harmless herb, and it interacts with SSRIs in two overlapping and hard-to-predict ways. The result is a combination most clinicians prefer to avoid rather than manage.
st. john's wortssridrug interactiondrug supplement interactionsupplement interactionsupplement interactionsmedication timingabsorption