soluble fiber
4 interactions related to soluble fiber
psyllium + metformin
Psyllium forms a viscous gel that can physically trap metformin in the gut and slow its absorption, potentially reducing peak plasma levels and blood-glucose control when both are taken simultaneously. Soluble fiber can also independently lower postprandial glucose, which may compound metformin's hypoglycemic effect.
psyllium + warfarin
Psyllium is a soluble fiber that forms a viscous gel in the gut, which can trap warfarin and slow or reduce its absorption when taken at the same time. Significant changes in fiber intake may also alter gut flora vitamin K production, indirectly destabilizing INR.
oat fiber + statins
Oat bran is a soluble fiber rich in beta-glucan that can bind statins in the gut and slow their absorption, reducing the cholesterol-lowering effect when both are taken simultaneously. Animal data show oat bran taken with atorvastatin reduced the lipid-lowering effect by roughly 50 percent at low statin doses.
glucomannan + metformin
Glucomannan is a highly viscous soluble fiber that swells dramatically in the gut and can bind metformin, reducing its absorption when both are taken together. Glucomannan also has independent glucose-lowering effects that may compound metformin's action and increase the risk of hypoglycemia.