side effects
2 interactions related to side effects
methotrexate + folate
Methotrexate works by inhibiting dihydrofolate reductase, depleting active folate and causing GI, mucosal, and hepatic side effects. Folic acid supplementation reduces those side effects by 26-77% without compromising efficacy, but must be timed correctly to avoid blunting the drug's action.
methotrexatefolatefolic acidrheumatoid arthritisdihydrofolate reductaseside effectssupplementationtiming
smoking + varenicline
Varenicline (Chantix) is a partial agonist at the alpha4-beta2 nicotinic acetylcholine receptor; continued smoking or concurrent nicotine replacement therapy can increase side effects such as nausea, headache, vomiting, dizziness, and fatigue. Varenicline blocks much of nicotine's rewarding effect.
smokingvareniclinechantixsmoking cessationnicotine receptorpartial agonistnauseaside effectsquit smokingnrt