senescence

fisetin + quercetin

Fisetin and quercetin are structurally related dietary flavonols with overlapping antioxidant and anti-inflammatory activity, both studied as candidate senolytics. They are often combined in longevity-oriented supplement stacks, but the robust human senolytic evidence is for dasatinib plus quercetin, not for the fisetin-plus-quercetin pairing, which rests largely on animal and mechanistic data. The combination is generally well tolerated; the main practical consideration is that both flavonoids can affect platelet function and drug metabolism, so anyone on prescription medication should check with a clinician.