selegiline
2 interactions related to selegiline
maoi + 5-htp
5-HTP is the direct precursor to serotonin and bypasses the rate-limiting step of serotonin synthesis. Combined with an MAOI, which blocks serotonin breakdown, intracellular and synaptic serotonin can rise to toxic levels, producing serotonin syndrome.
maoi5-htpserotonin syndromephenelzinetranylcypromineselegilinecontraindicationdepressionsupplement
yerba mate + maois
Yerba mate contains caffeine plus trace monoamine oxidase inhibitor-like compounds, but its bigger risk with prescription MAOIs (phenelzine, tranylcypromine, isocarboxazid, selegiline) is its sympathomimetic load: caffeine, theobromine, and modest tyramine content can amplify the pressor response in patients with inhibited MAO. Combining the two can trigger hypertensive crisis or serotonergic adverse effects.
yerba matemaoiphenelzinetranylcypromineselegilinetyraminehypertensive crisispsychiatric medication