selegiline
2 interactions related to selegiline
maoi + 5-htp
5-HTP is the direct precursor to serotonin and bypasses the rate-limiting step of serotonin synthesis. Combined with an MAOI, which blocks serotonin breakdown, serotonin can rise to dangerous levels and trigger serotonin syndrome, a potentially life-threatening reaction.
yerba mate + maois
Yerba mate is a caffeine-rich infusion. On a non-selective MAOI (phenelzine, tranylcypromine, isocarboxazid), the enzyme that normally clears tyramine and tempers sympathetic tone is blocked, so a high caffeine and methylxanthine load plus any tyramine the brew carries can amplify the pressor response and push blood pressure into dangerous territory. The yerba-mate-specific risk is extrapolated from documented caffeine-plus-MAOI cases, not from direct mate studies.