seizure
2 interactions related to seizure
star fruit + phenytoin
Star fruit (Averrhoa carambola) contains caramboxin, a neurotoxin that excites neurons, plus soluble oxalates that can injure the kidneys. In people with reduced kidney function, who cannot clear caramboxin, eating star fruit has triggered intractable seizures and status epilepticus. This is the fruit's own toxicity rather than a chemical reaction with phenytoin, but for someone taking phenytoin to prevent seizures it adds a serious, avoidable risk.
alcohol + tramadol
Tramadol combined with alcohol produces additive central nervous system and respiratory depression, and the combination lowers the seizure threshold, increasing the risk of convulsions, serotonin-related reactions, and life-threatening overdose. Tramadol's serotonergic and noradrenergic activity makes this pairing more hazardous than alcohol with a typical opioid.