seizure
2 interactions related to seizure
star fruit + phenytoin
Star fruit (Averrhoa carambola) contains caramboxin, a neurotoxin that activates excitatory neuroreceptors and inhibits GABA, and high oxalate content that causes acute kidney injury. In patients with renal impairment, star fruit ingestion has triggered refractory status epilepticus, directly antagonizing phenytoin's seizure-prevention purpose.
star fruitcarambolaphenytoinseizurestatus epilepticuscaramboxinepilepsynephrotoxicitycase report
alcohol + tramadol
Tramadol combined with alcohol produces additive CNS and respiratory depression, and the combination significantly lowers the seizure threshold, increasing the risk of convulsions, serotonin syndrome, and overdose death. Tramadol has unique serotonergic and noradrenergic activity that compounds alcohol's effects beyond what occurs with pure opioids.
alcoholtramadolopioidseizureserotonin syndromerespiratory depressioncns depressantoverdose