1 interaction related to salicylates
Aspirin and other salicylates push valproate off its plasma-protein binding sites and slow one of its breakdown pathways, so the active, unbound portion of valproate can rise even when the standard total valproate blood level looks unchanged. This can mask a clinically meaningful increase in active drug and raise the risk of valproate toxicity such as sedation, tremor, confusion, raised ammonia, and liver strain, while aspirin's own anti-clotting effect adds to valproate's tendency to lower platelets.
