1 interaction related to revatio
Sildenafil is broken down mainly by the gut and liver enzyme CYP3A4. Grapefruit juice contains furanocoumarins that block intestinal CYP3A4, modestly raising sildenafil exposure and delaying its peak. This can amplify the headache, flushing, dizziness, and transient blood-pressure drop that are typical of PDE5 inhibitors.
