retinol
2 interactions related to retinol
vitamin d3 + vitamin a
Vitamin D (via VDR) and vitamin A (via RXR, the obligate heterodimer partner of VDR) bind together at vitamin D response elements to drive gene transcription for immunity, bone, and epithelial differentiation. Adequate levels of both are needed for optimal signaling, but at very high doses they can antagonize each other for bone and calcium endpoints.
vitamin d3vitamin aretinolimmune supportvdrrxrbone healthfat-soluble vitamins
alcohol + vitamin a
Alcohol depletes hepatic vitamin A by inducing cytochrome P450 enzymes (especially CYP2E1, CYP26A1, CYP26B1) that catabolize retinol. Paradoxically, vitamin A supplementation in heavy drinkers is hepatotoxic — alcohol potentiates retinol's toxicity to liver cells, and high-dose beta-carotene combined with alcohol increases liver injury.
alcoholvitamin aretinolbeta caroteneliver diseasehepatotoxicitycyp2e1carotenoid