1 interaction related to rapamune
Sirolimus is a CYP3A4 and P-glycoprotein substrate with a narrow therapeutic window and high patient-to-patient variability. The FDA-approved Rapamune label states that grapefruit juice inhibits the CYP3A4-mediated metabolism of sirolimus and must not be taken with, or used to dilute, the drug, because unpredictable rises in blood levels can cause toxicity and threaten the transplanted organ.
