raas
3 interactions related to raas
losartan + potassium
Losartan blocks the angiotensin II receptor, lowering aldosterone and reducing the amount of potassium the kidneys excrete. Adding concentrated potassium supplements or potassium-based salt substitutes can push serum potassium toward the hyperkalemic range, which carries cardiac arrhythmia risk in people with kidney impairment, diabetes, or heart failure. Routine monotherapy raises measured potassium only modestly in people with healthy kidneys, but the safety margin narrows once supplements or other potassium-raising drugs are added.
lisinopril + potassium
Lisinopril blocks the renin-angiotensin-aldosterone system, lowering aldosterone and reducing the kidneys' ability to excrete potassium. Adding a potassium supplement or potassium-based salt substitute on top can push blood potassium into a dangerous range (hyperkalemia), especially in older adults or people with reduced kidney function.
valsartan + potassium
Valsartan is an angiotensin II receptor blocker that suppresses aldosterone, which slows the kidneys' excretion of potassium. The FDA-approved Diovan label warns that potassium supplements and potassium-containing salt substitutes may raise serum potassium to clinically significant levels, particularly in people with reduced kidney function, diabetes, or heart failure.