raas
3 interactions related to raas
losartan + potassium
Losartan blocks the angiotensin II receptor, lowering aldosterone and reducing renal potassium excretion in the same way ACE inhibitors do. Concurrent potassium supplementation can drive serum potassium into the hyperkalemic range, with cardiac arrhythmia risk in patients with kidney impairment, diabetes, or heart failure.
lisinopril + potassium
Lisinopril blocks the renin-angiotensin-aldosterone system, reducing aldosterone secretion and impairing the kidneys' ability to excrete potassium. Adding potassium supplements on top of this can push serum potassium into dangerous territory, especially in older adults or those with reduced kidney function.
valsartan + potassium
Valsartan is an angiotensin II receptor blocker that suppresses aldosterone and slows renal potassium excretion. The FDA-approved Diovan label specifically warns that potassium supplements and potassium-containing salt substitutes may lead to clinically significant hyperkalemia, particularly in patients with renal impairment, diabetes, or heart failure.