pyridoxine
2 interactions related to pyridoxine
oral contraceptives + vitamin b6
Combined (estrogen-containing) oral contraceptives modestly lower the active form of vitamin B6, pyridoxal 5'-phosphate, by speeding up tryptophan metabolism. Long-term pill users tend to show lower B6 status markers than non-users. This is a depletion of a status marker rather than a clinical safety problem, and it does not affect how well the pill works.
levetiracetam + vitamin b6
Levetiracetam (Keppra) commonly causes behavioral side effects including irritability, agitation, anxiety, and mood changes (sometimes called 'Keppra rage'). Randomized trials and case series in children and adults suggest that adding pyridoxine (vitamin B6) eases these behavioral symptoms in a meaningful subset of patients, though the evidence is mixed: two pediatric trials were positive while one adult trial was null. This is a potential benefit, not a harmful interaction.