pyridoxine
2 interactions related to pyridoxine
oral contraceptives + vitamin b6
Combined oral contraceptives lower pyridoxal 5'-phosphate (the active form of vitamin B6) by altering tryptophan metabolism and increasing B6 turnover. Long-term pill users have lower B6 status than non-users, which may contribute to mood symptoms in some women.
oral contraceptivesbirth controlvitamin b6pyridoxinenutrient depletiontryptophan metabolismmoodsupplementation
levetiracetam + vitamin b6
Levetiracetam (Keppra) commonly causes behavioral side effects including irritability, agitation, anxiety, and mood changes (sometimes called 'Keppra rage'). Several observational studies and case series in both pediatric and veteran populations suggest that adjunctive pyridoxine (vitamin B6) supplementation reduces these behavioral symptoms in roughly 40-50% of patients, though randomized controlled trial data are mixed.
levetiracetamkeppravitamin b6pyridoxineirritabilitybehavioral side effectsepilepsyanticonvulsantkeppra rage