psyllium
3 interactions related to psyllium
psyllium + metformin
Psyllium forms a viscous gel that can physically trap metformin in the gut and slow its absorption, potentially reducing peak plasma levels and blood-glucose control when both are taken simultaneously. Soluble fiber can also independently lower postprandial glucose, which may compound metformin's hypoglycemic effect.
psyllium + warfarin
Psyllium is a soluble fiber that forms a viscous gel in the gut, which can trap warfarin and slow or reduce its absorption when taken at the same time. Significant changes in fiber intake may also alter gut flora vitamin K production, indirectly destabilizing INR.
levothyroxine + fiber
Dietary and supplemental fiber can adsorb levothyroxine in the gut and reduce its bioavailability, leading to higher TSH and unstable dosing when fiber intake is high or variable. The effect has been demonstrated with high-fiber diets and pharmaceutical fiber supplements such as psyllium.