1 interaction related to protonix
Pantoprazole, like all PPIs, is associated with hypomagnesemia after long-term use, likely via impaired active intestinal magnesium transport (TRPM6/TRPM7). The FDA included pantoprazole in its 2011 Drug Safety Communication on PPI-induced hypomagnesemia, which can cause arrhythmia, tetany, and seizures.