prograf
2 interactions related to prograf
cranberry + tacrolimus
Cranberry juice has been shown to inhibit intestinal CYP3A enzymes, and tacrolimus is heavily metabolized by intestinal CYP3A4 and CYP3A5. The expected direction is an increase in tacrolimus trough levels, raising the risk of nephrotoxicity and tremor, although published cases are scarce and one case unexpectedly reported a decrease.
cranberrytacrolimustransplantcyp3a4immunosuppressantprografdrug interactionnephrotoxicity
lactobacillus + tacrolimus
Tacrolimus is a calcineurin-inhibitor immunosuppressant used after solid-organ transplant. Lactobacillus species have caused bacteremia, endocarditis, and liver abscess in transplant recipients on tacrolimus, including a published case of recurrent Lactobacillus rhamnosus bacteremia in a renal transplant patient.
lactobacillustacrolimusprograftransplantbacteremiacalcineurin inhibitorimmunosuppressionrenal transplant