polyphenols
8 interactions related to polyphenols
black tea + iron
Black tea is rich in polyphenols (tannins) that bind iron in the digestive tract. When the two are taken together, less of the iron your body needs gets absorbed.
black tea + thiamine
Black tea contains antithiamine factors - polyphenols such as tannins and chlorogenic acid - that can oxidise thiamine (vitamin B1) into biologically inactive forms in the gut before it is absorbed. Heavy habitual tea consumption has been linked to lower thiamine status, mainly in people whose dietary B1 intake is already marginal. For most well-nourished adults the effect is modest.
green tea + iron
Green tea polyphenols, especially the catechin EGCG, bind non-heme iron in the gut and form insoluble complexes that the intestine cannot absorb. The effect is most pronounced when green tea is consumed together with an iron supplement or an iron-rich plant meal, and it can be blunted by spacing the two apart and by pairing iron with a vitamin C source.
peppermint tea + iron
Peppermint tea is rich in plant polyphenols and tannins (including rosmarinic acid) that bind non-heme iron in the gut, forming insoluble complexes the body cannot absorb. Human studies show peppermint tea substantially reduces non-heme iron absorption from a meal, placing it among the stronger natural inhibitors. Heme iron from meat, poultry, and fish is not affected.
coffee + vitamin b1
Coffee and tea were historically labeled antithiamine beverages, but later biochemistry walked the claim back: chlorogenic and caffeic acids do not destroy thiamine under physiological conditions, and the real activity comes from polyphenol oxidation products and tannins, which are lower in coffee than tea. The net effect on thiamine status is modest and unlikely to matter for well-nourished people; it becomes relevant only on a marginal diet or in groups already prone to deficiency.
curcumin + quercetin
In laboratory intestinal-cell models, quercetin slows the gut and liver enzymes (UDP-glucuronosyltransferase and CYP3A4) that normally break curcumin down quickly, which raised curcumin's measured permeability across the cell layer. Both polyphenols also act on overlapping anti-inflammatory and antioxidant pathways. The evidence is mechanistic and limited to in vitro work — no human trials have confirmed a real-world bioavailability or anti-inflammatory benefit from combining them.
oolong tea + iron
Oolong tea is partially oxidised and contains the same families of iron-binding polyphenols found in green and black tea, including catechins and theaflavins. These polyphenols can bind non-heme iron in the gut and lower how much is absorbed when tea is taken with iron-rich meals or supplements. The effect is well documented for green and black tea; for oolong specifically it is a reasonable extrapolation of the same mechanism rather than a directly measured result.
coffee + iron
Coffee contains chlorogenic acid and other polyphenols with galloyl groups that bind non-heme iron in the gut, forming poorly soluble complexes the intestine cannot absorb. Drinking coffee with or shortly after an iron-rich meal or supplement meaningfully reduces how much non-heme iron you take up.