polyphenol
2 interactions related to polyphenol
spermidine + resveratrol
Spermidine and resveratrol both induce autophagy but through different upstream mechanisms: spermidine inhibits histone acetyltransferases (lowering histone acetylation), while resveratrol activates the sirtuin SIRT1 (a deacetylase). The two converge on the acetylproteome and have been shown to synergize at low doses for autophagy induction and lifespan extension in model organisms.
fisetin + quercetin
Fisetin and quercetin are structurally related flavonols with overlapping but distinct senolytic and anti-inflammatory mechanisms. Fisetin was identified in a Mayo Clinic screen as the most potent natural senolytic, while quercetin has been clinically tested as part of the dasatinib + quercetin senolytic combination, and the two together broaden the senolytic and antioxidant coverage.