platelet function
2 interactions related to platelet function
alcohol + ibuprofen
Alcohol and ibuprofen each independently irritate the gastric lining and impair platelet function, and together they significantly increase the risk of gastrointestinal bleeding, ulcers, and acute kidney injury. Chronic combined use also accelerates kidney damage through dehydration and reduced renal perfusion.
vitamin e + platelet function test
High-dose vitamin E (alpha-tocopherol above 400 IU per day) inhibits platelet aggregation through a protein kinase C-dependent mechanism, producing prolonged bleeding times and abnormal results on platelet function analyzers (such as PFA-100, VerifyNow, and light transmission aggregometry). The effect is most pronounced when vitamin E is combined with aspirin or other antiplatelet agents and can interfere with workup for bleeding disorders.