platelet aggregation
2 interactions related to platelet aggregation
aspirin + ginkgo
Ginkgo biloba can inhibit platelet-activating factor (PAF) and platelet aggregation, which may add to aspirin's irreversible inhibition of cyclooxygenase-1 and thromboxane A2. Observational data suggest a modest increase in minor bleeding events when the two are combined, and there are case reports of more serious bleeds in vulnerable patients, though a controlled trial found no measurable added effect on platelet function.
clopidogrel + ginkgo
Clopidogrel blocks the platelet P2Y12 ADP receptor, while ginkgo biloba inhibits platelet-activating factor through a separate pathway. A controlled healthy-volunteer study found no measurable added platelet inhibition, but case reports and an observational analysis link the combination to bleeding. The realistic concern is a modest, additive bleeding risk, most relevant in older patients and those also taking aspirin.