platelet aggregation
2 interactions related to platelet aggregation
aspirin + ginkgo
Ginkgo biloba can inhibit platelet-activating factor (PAF) and platelet aggregation, which can add to aspirin's irreversible inhibition of cyclooxygenase-1 and thromboxane A2. The combination may modestly increase minor bleeding events, with case reports of more serious bleeds in vulnerable patients.
aspiringinkgoantiplateletbleedingsalicylateherb-drug interactionplatelet aggregation
clopidogrel + ginkgo
Ginkgo biloba inhibits platelet-activating factor and may add to clopidogrel's blockade of the platelet P2Y12 ADP receptor. While a healthy-volunteer study did not detect additive platelet inhibition, observational and case-report data link the combination to increased bleeding, including intracranial hemorrhage.
clopidogrelginkgoantiplateletp2y12bleedingplatelet aggregationherb-drug interactionplavix