platelet
4 interactions related to platelet
cocoa + warfarin
Cocoa flavanols inhibit platelet adhesion and aggregation and can mildly prolong bleeding time. Layered on top of warfarin's anticoagulant effect, large or fluctuating intakes of cocoa can increase bleeding risk without necessarily moving the INR.
ibuprofen + ginkgo
Ibuprofen inhibits platelet aggregation through COX-1, and Ginkgo biloba inhibits platelet-activating factor through ginkgolide B. Combining them increases the risk of bleeding, with case reports of fatal intracerebral hemorrhage.
naproxen + fish oil
Naproxen impairs platelet aggregation through COX-1 inhibition, and fish oil EPA and DHA have mild antiplatelet and antithrombotic effects. Combining them can modestly increase bleeding risk, especially at high doses or alongside other blood thinners.
alcohol + aspirin
Alcohol and aspirin together significantly increase the risk of gastrointestinal bleeding because aspirin irreversibly inhibits platelets for their entire 7-10 day lifespan while alcohol damages the gastric lining and impairs clot formation. The risk is particularly elevated for daily low-dose aspirin users who drink regularly.