platelet
4 interactions related to platelet
cocoa + warfarin
Cocoa flavanols can modestly reduce platelet activity in people, which in theory could add to warfarin's anticoagulant effect. In practice the evidence is mechanistic only: no case reports or clinical studies show actual bleeding or a change in INR from cocoa in people taking warfarin. Keeping cocoa intake small and consistent is a sensible precaution rather than a response to a proven interaction.
ibuprofen + ginkgo
Ibuprofen reduces platelet aggregation through COX-1 inhibition, and Ginkgo biloba has antiplatelet activity through ginkgolide B's antagonism of platelet-activating factor. Used together they can compound the effect on platelets and raise bleeding risk; a fatal intracerebral hemorrhage has been reported in a long-term ginkgo user who started regular ibuprofen.
naproxen + fish oil
Naproxen and fish oil both mildly reduce platelet aggregation through separate pathways, so their effects are additive in theory. Pooled clinical-trial data show no meaningful increase in major bleeding at typical doses.
alcohol + aspirin
Aspirin and alcohol both damage the gastric lining and impair clotting; used together they raise the risk of upper gastrointestinal bleeding, with risk rising as alcohol intake and aspirin use increase.